Human Adaptation Research Articles

Skin colour: A window into human phenotypic evolution and environmental adaptation.

As modern humans ventured out of Africa and dispersed around the world, they faced novel environmental challenges that led to geographic adaptations including skin colour. Over the long history of human evolution, skin colour has changed dramatically, showing tremendous diversity across different geographical regions, for example, the majority of individuals from the expansive lands of Africa have darker skin, whereas the majority of people from Eurasia exhibit lighter skin. What adaptations did lighter skin confer upon modern humans as they migrated from Africa to Eurasia? What genetic mechanisms underlie the diversity of skin colour observed in different populations? In recent years, scientists have gradually gained a deeper understanding of the interactions between pigmentation gene and skin colour through population-based genomic studies of different groups around the world, particularly in East Asia and Africa. In this review, we summarize our current understanding of 26 skin colour-related pigmentation genes and 48 SNPs that influence skin colour. Important pigmentation genes across three major populations are described in detail: MFSD12, SLC24A5, PDPK1 and DDB1/CYB561A3/TMEM138 influence skin colour in African populations; OCA2, KITLG, SLC24A2, GNPAT and PAH are key to the evolution of skin pigmentation in East Asian populations; and SLC24A5, SLC45A2, TYR, TYRP1, ASIP, MC1R and IRF4 significantly contribute to the lightening of skin colour in European populations. We summarized recent findings in genomic studies of skin colour in populations that implicate diverse geographic environments, local adaptation among populations, gene flow and multi-gene interactions as factors influencing skin colour diversity.

Shades of gravity - effects of planetary gravity levels on electrocortical activity and neurocognitive performance.

The plans of international space agencies to return to the Moon and explore deep space, including Mars, highlight the challenges of human adaptation and stress the need for a thorough analysis of the factors that facilitate, limit and modify human performance under extreme environments. This study investigates the influence of partial gravity on behavioural (error rate and reaction time) and neuronal parameters (event-related potentials) through parabolic flights. Brain cortical activity was assessed using EEG from 18 participants who solved a neurocognitive task, consisting of a mental arithmetic task and an auditory oddball paradigm, during Earth (1G), Lunar (0.16G + 0.25G) and Martian gravity (0.38G + 0.5G) for 15 consecutive parabolas. Data shows higher electrocortical activity in Earth gravity compared to Lunar and Martian gravity in the parietal lobe. No differences in participants' performance were found among the gravity levels. Event-related potentials displayed gravity-dependent variations, though limited stimuli recording suggests caution in interpretation. Data suggests a threshold between Earth and Martian gravity within the different gravities responsible for physiological changes, but it seems to vary greatly between individuals. The altered neuronal communication could be explained with a model developed by Kohn and Ritzmann in 2018. The increasing intracranial pressure in weightlessness changes the properties of the cell membrane of neurons and leads to a depolarisation of the resting membrane potential. The findings underscore the individuality of physiological changes in response to gravity alterations, signalling the need for further investigations in future studies.

CHRFAM7A diversifies human immune adaption through Ca2+ signalling and actin cytoskeleton reorganization

Human restricted genes contribute to human specific traits in the immune system. CHRFAM7A, a uniquely human fusion gene, is a negative regulator of the α7 nicotinic acetylcholine receptor (α7 nAChR), the highest Ca2+ conductor of the ACh receptors implicated in innate immunity. Understanding the mechanism of how CHRFAM7A affects the immune system remains unexplored. Two model systems are used, human induced pluripotent stem cells (iPSC) and human primary monocytes, to characterize α7 nAChR function, Ca2+ dynamics and decoders to elucidate the pathway from receptor to phenotype. CHRFAM7A/α7 nAChR is identified as a hypomorphic receptor with mitigated Ca2+ influx and prolonged channel closed state. This shifts the Ca2+ reservoir from the extracellular space to the endoplasmic reticulum (ER) leading to Ca2+ dynamic changes. Ca2+ decoder small GTPase Rac1 is then activated, reorganizing the actin cytoskeleton. Observed actin mediated phenotypes include cellular adhesion, motility, phagocytosis and tissue mechanosensation. CHRFAM7A introduces an additional, human specific, layer to Ca2+ regulation leading to an innate immune gain of function. Through the actin cytoskeleton it drives adaptation to the mechanical properties of the tissue environment leading to an ability to invade previously immune restricted niches. Human genetic diversity predicts profound translational significance as its understanding builds the foundation for successful treatments for infectious diseases, sepsis, and cancer metastasis. This work is supported in part by the Community Foundation for Greater Buffalo (Kinga Szigeti) and in part by NIH grant R01HL163168 (Yongho Bae).

Frequent disturbances enhanced the resilience of past human populations.

The record of past human adaptations provides crucial lessons for guiding responses to crises in the future1-3. To date, there have been no systematic global comparisons of humans' ability to absorb and recover from disturbances through time4,5. Here we synthesized resilience across a broad sample of prehistoric population time-frequency data, spanning 30,000 years of human history. Cross-sectional and longitudinal analyses of population decline show that frequent disturbances enhance a population's capacity to resist and recover from later downturns. Land-use patterns are important mediators of the strength of this positive association: farming and herding societies are more vulnerable but also more resilient overall. The results show that important trade-offs exist when adopting new or alternative land-use strategies.

Exploring the Evolution of Educational Methods: Perspectives from Imaginative Culture and Human Nature

Education is a fundamental pillar in human development, and its evolution throughout history has been influenced by a variety of factors, including imaginative culture and human nature. In this study, we explore how educational methods have evolved in response to the interaction between these two aspects. We look at how human creativity, imagination, and adaptation have influenced the way we teach and learn, from early forms of knowledge transmission to more contemporary approaches focused on active student engagement and the development of practical skills. Our research is based on a comprehensive review of the academic literature in the fields of education, evolutionary psychology, cultural anthropology, and imagination studies. We explore how societies have used imagination as a tool to transmit knowledge and values, as well as to foster creativity and individual expression. We also examine how adaptive aspects of human nature, such as the ability to learn collaboratively and adapt to changing environments, have influenced the way educational methods are designed. Our results show a clear evolution in educational methods over time, from approaches focused on the one-way transmission of knowledge to more interactive and participatory models that encourage exploration and discovery. We identify common patterns in the way societies have used imagination and adaptation to promote learning and socialization and discuss the implications of these findings for contemporary education. In conclusion, this study highlights the importance of understanding the relationship between imaginative culture, human nature, and education. It provides a solid foundation for the design of educational methods that harness the innate creativity and adaptability of human beings and offers guidance for educators and policymakers on how to promote meaningful and lasting learning in today's world.

Duyu Bütünleme Sistemleri ile Eğitim İlişkisinde Nörolojik Fonksiyonların İncelenmesi

The aim of this study is to investigate the neurological functions in the relationship between sensory integration systems and education. Sensory integration, first of all, Occupational Therapist A. It was described by Jean Ayres as expressing a neurological process that allows us to make sense of our world by taking, recording, modulating, organizing and interpreting information from our senses to our brain. Neuroplasticity, which is the main component of sensory integration, is defined as changes in the structural properties and functions of neurons and synapses provided by these neurons in the brain depending on environmental stimuli. It has been argued in various studies examining the relationship between learning and brain cells that new axon strands occur Decently in neurons as a result of the learning process. According to this, the formation of new synaptic connections is due to each learning experience. Excessive use of synaptic connections in the brain leads to a strengthening of these connections. If these connections are not used, they will die and disappear. The development process of the brain is in the form of the formation (release of knots) and pruning of synaptic connections Tue. For this reason, constant stimulation of the brain with enriched experiences for the brain is important in the development of the brain. In ancient times, people thought that when they got older, their brains became stable. In recent years, due to technological developments, it has been understood that the human brain adapts to innovations that do not stop. In other words, the concept of flexibility of nerves, which we call neuroplasticity, has emerged. Key Words: Sensory Integration, Education, Neurological Functions

New Late Pleistocene age for the Homo sapiens skeleton from Liujiang southern China

The emergence of Homo sapiens in Eastern Asia is a topic of significant research interest. However, well-preserved human fossils in secure, dateable contexts in this region are extremely rare, and often the subject of intense debate owing to stratigraphic and geochronological problems. Tongtianyan cave, in Liujiang District of Liuzhou City, southern China is one of the most important fossils finds of H. sapiens, though its age has been debated, with chronometric dates ranging from the late Middle Pleistocene to the early Late Pleistocene. Here we provide new age estimates and revised provenience information for the Liujiang human fossils, which represent one of the most complete fossil skeletons of H. sapiens in China. U-series dating on the human fossils and radiocarbon and optically stimulated luminescence dating on the fossil-bearing sediments provided ages ranging from ~33,000 to 23,000 years ago (ka). The revised age estimates correspond with the dates of other human fossils in northern China, at Tianyuan Cave (~40.8–38.1 ka) and Zhoukoudian Upper Cave (39.0–36.3 ka), indicating the geographically widespread presence of H. sapiens across Eastern Asia in the Late Pleistocene, which is significant for better understanding human dispersals and adaptations in the region.

Advancement in ice-jam flood risk management: Integrating dynamic adaptive behavior by an agent-based modeling in Fort McMurry, Canada

Ice-jam flooding is a prevalent extreme event that impacts flood hazard and vulnerability. We introduce a conceptual model framework for Dynamic Ice-jam Flood Risk Assessment (DIFRA). DIFRA integrates ice-jam flood hazard, ice-jam flood risk, and human adaptation. Using agent-based modeling, we captured top-down (artificial breakup) and bottom-up (flood-proofing) adaptive behavior. Our study in Fort McMurray, Canada, shows the complex interaction between micro-level behaviors and macro-level phenomena over time. Our variance-based global sensitivity analysis shows the role of dynamic adaptive behavior in ice-jam flood risk, where the artificial breakage by the government can lead to a regime shift and a decrease in the ice-jam flood risk. However, it can also decrease the number of newly adapted residents to flood-proofing and the role of residents in ice-jam flood risk. DIFRA offers a comprehensive approach to understanding and managing ice-jam flood risk, with potential applications to similar riverine communities in cold regions.

Analisis Beban Kerja Mental saat Mengoperasikan Smartphone dengan Memperhatikan Postur Tubuh: Pendekatan Menggunakan Metode NASA-TLX

Work physiology is the study of understanding how the human body adapts and functions in the work environment. Occupational physiology involves the study of the body's physiological responses to work-related demands and stress. This understanding is necessary to protect workers' health and welfare, as well as increase work productivity and efficiency. This research aims to analyze physiological workload by focusing on measuring mental workload, using the NASA-TLX method. Research activities were carried out on 12 students from the Department of Industrial Engineering, Universitas Mataram. Students were divided into 3 groups according to their assigned work posture, namely standing (Group A), sitting (Group B), and lying down (Group C). The results showed that the order of subjects with the highest mental workload was subject 1A (78.97%) with a standing posture, 2B (77.33%) with a sitting posture, and 4A (73.57%) with a standing posture. Based on these results, the final conclusion that can be drawn is that the mental workload in standing and sitting postures is what is most felt by the subject when operating the smartphone. These results conclude that different postures when operating a smartphone can affect the user's mental workload Keywords: Mental, NASA-TLX, Posture, Smartphone, Workload.

Genome and clonal hematopoiesis stability contrasts with immune, cfDNA, mitochondrial, and telomere length changes during short duration spaceflight.

The Inspiration4 (I4) mission, the first all-civilian orbital flight mission, investigated the physiological effects of short-duration spaceflight through a multi-omic approach. Despite advances, there remains much to learn about human adaptation to spaceflight's unique challenges, including microgravity, immune system perturbations, and radiation exposure. To provide a detailed genetics analysis of the mission, we collected dried blood spots pre-, during, and post-flight for DNA extraction. Telomere length was measured by quantitative PCR, while whole genome and cfDNA sequencing provided insight into genomic stability and immune adaptations. A robust bioinformatic pipeline was used for data analysis, including variant calling to assess mutational burden. Telomere elongation occurred during spaceflight and shortened after return to Earth. Cell-free DNA analysis revealed increased immune cell signatures post-flight. No significant clonal hematopoiesis of indeterminate potential (CHIP) or whole-genome instability was observed. The long-term gene expression changes across immune cells suggested cellular adaptations to the space environment persisting months post-flight. Our findings provide valuable insights into the physiological consequences of short-duration spaceflight, with telomere dynamics and immune cell gene expression adapting to spaceflight and persisting after return to Earth. CHIP sequencing data will serve as a reference point for studying the early development of CHIP in astronauts, an understudied phenomenon as previous studies have focused on career astronauts. This study will serve as a reference point for future commercial and non-commercial spaceflight, low Earth orbit (LEO) missions, and deep-space exploration.

Prehistoric ornaments in a changing environment. An integrated approach to the Late Upper Palaeolithic and Mesolithic Columbella rustica shells from the Vlakno cave, Croatia

This paper advances knowledge of human behavioural and adaptational strategies in coastal areas related to acquiring, producing and distributing ornaments, specifically, the omnipresent marine gastropod Columbella rustica. By applying quantitative and qualitative approaches to the most extensive collection of Columbella rustica shells in the Eastern Adriatic region discovered in the Late Upper Palaeolithic and Mesolithic levels of Vlakno cave in Croatia, we have determined the complete step-by-step life cycle of this bead type, in particular, where and how shells were collected, produced, used, distributed and discarded. By integrating different methodologies, our data revealed changes in the collection strategies, reduction of the shell size during the Mesolithic period, and standardisation and continuity in production techniques. Detailed analyses of broken shells in the archaeological assemblage identified the presence of technological traces resulting from processing mistakes, supporting our hypothesis of on-site production. A significant share of used and unused standardised beads points that bead production at this site was for personal use but also likely for the exchange and distribution systems. Standardised, systematic and long-lasting activity related to the ornaments places Vlakno cave as one of the leading centres for maintaining regional exchange and communication networks in the Eastern Adriatic region during significant climatic and environmental changes happening in this region in the Late Pleniglacial and the early Holocene. Detecting on-site activities related to the ornaments in Vlakno cave has extended our understanding of how symbolic motives influenced the settlement model of the Late Pleniglacial and Early Holocene hunter-gatherers in Eastern Adriatic region and overall contributed to fundamental questions about the complexity of ancient human societies' adaptation strategies.

Integration between spirituality and psychology in the transformation of body, mind, and soul of the human person with an encounter with the divine

This study delves into the dynamics between theology and psychology, exploring the historical attitudes held by practitioners in each field. Historically, psychology has often overlooked the role of religion in shaping human behaviour and cognition, leading to a fragmented understanding of the human experience. The neglect of spirituality has limited the effectiveness of psychological research in addressing the complex interplay between mind, body, and soul. This study adopts a literature review methodology drawing from psychology, theology, and neuroscience. Data analysis revealed a significant correlation between religious beliefs/practices and human adaptation, highlighting the importance of integrating religious factors into psychological research paradigms. Moreover, recent developments suggest increasing recognition of the interface between religion and psychology, indicating promising collaboration and further exploration opportunities. The study recommends fostering greater collaboration and dialogue between psychology and theology. By synthesising insights from psychology and theology, practitioners, policymakers, and researchers can develop more holistic interventions that promote human flourishing and facilitate individuals' spiritual growth. Therefore, future research should explore and deepen the synergies between psychology and theology, aiming to cultivate a more profound understanding of human nature and harness the transformative power of spirituality in enhancing the overall quality of life.

Recombinant probiotic Lactococcus lactis delivering P62 mitigates moderate colitis in mice.

p62 is a human multifunctional adaptor protein involved in key cellular processes such as tissue homeostasis, inflammation, and cancer. It acts as a negative regulator of inflammasome complexes. It may thus be considered a good candidate for therapeutic use in inflammatory bowel diseases (IBD), such as colitis. Probiotics, including recombinant probiotic strains producing or delivering therapeutic biomolecules to the host mucosal surfaces, could help prevent and mitigate chronic intestinal inflammation. The objective of the present study was to combine the intrinsic immunomodulatory properties of the probiotic Lactococcus lactis NCDO2118 with its ability to deliver health-promoting molecules to enhance its protective and preventive effects in the context of ulcerative colitis (UC). This study was realized in vivo in which mice were supplemented with the recombinant strain. The intestinal barrier function was analyzed by monitoring permeability, secretory IgA total levels, mucin expression, and tight junction genes. Its integrity was evaluated by histological analyses. Regarding inflammation, colonic cytokine levels, myeloperoxidase (MPO), and expression of key genes were monitored. The intestinal microbiota composition was investigated using 16S rRNA Gene Sequencing. No protective effect of L. lactis NCDO2118 pExu:p62 was observed regarding mice clinical parameters compared to the L. lactis NCDO2118 pExu: empty. However, the recombinant strain, expressing p62, increased the goblet cell counts, upregulated Muc2 gene expression in the colon, and downregulated pro-inflammatory cytokines Tnf and Ifng when compared to L. lactis NCDO2118 pExu: empty and inflamed groups. This recombinant strain also decreased colonic MPO activity. No difference in the intestinal microbiota was observed between all treatments. Altogether, our results show that recombinant L. lactis NCDO2118 delivering p62 protein protected the intestinal mucosa and mitigated inflammatory damages caused by dextran sodium sulfate (DSS). We thus suggest that p62 may constitute part of a therapeutic approach targeting inflammation.

The Evolution of Agrarian Landscapes in the Tropical Andes.

Changes in land-use practices have been a central element of human adaptation to Holocene climate change. Many practices that result in the short-term stabilization of socio-natural systems, however, have longer-term, unanticipated consequences that present cascading challenges for human subsistence strategies and opportunities for subsequent adaptations. Investigating complex sequences of interaction between climate change and human land-use in the past-rather than short-term causes and effects-is therefore essential for understanding processes of adaptation and change, but this approach has been stymied by a lack of suitably-scaled paleoecological data. Through a high-resolution paleoecological analysis, we provide a 7000-year history of changing climate and land management around Lake Acopia in the Andes of southern Peru. We identify evidence of the onset of pastoralism, maize cultivation, and possibly cultivation of quinoa and potatoes to form a complex agrarian landscape by c. 4300 years ago. Cumulative interactive climate-cultivation effects resulting in erosion ended abruptly c. 2300 years ago. After this time, reduced sedimentation rates are attributed to the construction and use of agricultural terraces within the catchment of the lake. These results provide new insights into the role of humans in the manufacture of Andean landscapes and the incremental, adaptive processes through which land-use practices take shape.

Exome sequencing in extreme altitude mountaineers identifies pathogenic variants in RTEL1 and COL6A1 previously associated with respiratory failure.

Adaptation of humans to challenging environmental conditions, such as extreme temperature, malnutrition, or hypoxia, is an interesting phenomenon for both basic and applied research. Identification of the genetic factors contributing to human adaptation to these conditions enhances our understanding of the underlying molecular and physiological mechanisms. In our study, we analyzed the exomes of 22 high altitude mountaineers to uncover genetic variants contributing to hypoxic adaptation. To our surprise, we identified two putative loss-of-function variants, rs1385101139 in RTEL1 and rs1002726737 in COL6A1 in two extremely high altitude (personal record of more than 8500 m) professional climbers. Both variants can be interpreted as pathogenic according to medical geneticists' guidelines, and are linked to inherited conditions involving respiratory failure (late-onset pulmonary fibrosis and severe Ullrich muscular dystrophy for rs1385101139 and rs1002726737, respectively). Our results suggest that a loss of gene function may act as an important factor of human adaptation, which is corroborated by previous reports in other human subjects.

419 Intramuscular immunization with rVCG-MECA vaccine elicits stronger chlamydial specific immune response than intranasal immunization

OBJECTIVES/GOALS: We prioritize Chlamydia’s public health impact, aim to develop rVCG-MECA for practical use, study robust immunity for effective strategies, and assess animal models for human vaccination adaptation. Our work highlights rVCG-MECA’s translational significance in public health. METHODS/STUDY POPULATION: Female Mice C57BL/6J mice (N=8) were immunized intramuscularly(IM) and intranasally(IN) and boosted twice, two weeks apart, with rVCG-MECA, once with live Chlamydia (C. trachomatis serovar D elementary bodies) and PBS. Specific mucosal and systemic immune responses were characterized. Vaccine efficacy was determined from chlamydia shedding following the transcervical challenge. Additionally, Chlamydia-specific cytokine (IFN-γ and IL-4) production by splenic and ILN T cells was assessed after 16 weeks RESULTS/ANTICIPATED RESULTS: Immunization with rVCG-MECA via intramuscular and intranasal routes triggered notable humoral responses in systemic and mucosal tissues. Intramuscular vaccination produced higher IgG2c levels in both tissues, while intranasal vaccination led to elevated IgA levels in mucosal tissues. rVCG-MECA-immunized mice exhibited significantly higher IFN-γ (Th1) secretion compared to IL-4 (Th2), with intramuscular immunization showing the highest IFN-γ levels. These findings anticipate robust immune responses, promising protection against Chlamydia, particularly through the intra muscular route. Overall, our results support rVCG-MECA as a promising Chlamydia vaccine, aligned with public health goals. DISCUSSION/SIGNIFICANCE: This study suggests that IM and IN immunization with rVCG-MECA induces immune effectors such as IFN-gamma and IgG2c that mediate chlamydial clearance in the genetical tract.

A Review of Anthropological Adaptations of Humans Living in Extreme Conditions and Health Implications

A Review of Anthropological Adaptations of Humans Living in Extreme Conditions and Health Implications

Human adaptation to heat in the context of climate change: A conceptual framework

Climate change is causing serious damage to natural and social systems, as well as having an impact on human health. Among the direct effects of climate change is the rise in global surface temperatures and the increase in the frequency, duration, intensity and severity of heat waves. In addition, understanding of the adaptation process of the exposed population remains limited, posing a challenge in accurately estimating heat-related morbidity and mortality. In this context, this study seeks to establish a conceptual framework that would make it easier to understand and organise knowledge about human adaptation to heat and the factors that may influence this process. An inductive approach based on grounded theory was used, through the analysis of case studies connecting concepts. The proposed conceptual framework is made up of five components (climate change, vulnerability, health risks of heat, axes of inequality and health outcomes), three heat-adaptation domains (physiological, cultural and political), two levels (individual and social), and the pre-existing before a heat event. The application of this conceptual framework facilitates the assistance of decision-makers in planning and implementing effective adaptation measures. Recognizing the importance of addressing heat adaptation as a health problem that calls for political solutions and social changes. Accordingly, this requires a multidisciplinary approach that would foster the participation and collaboration of multiple actors for the purpose of proposing effective measures to address the health impact of the rise in temperature.

The human microbiota is a beneficial reservoir for SARS-CoV-2 mutations.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mutations are rapidly emerging, in particular advantageous mutations in the spike (S) protein, which either increase transmissibility or lead to immune escape and are posing a major challenge to pandemic prevention and treatment. However, how the virus acquires a high number of advantageous mutations in a short time remains a mystery. Here, we provide evidence that the human microbiota is a reservoir of advantageous mutations and aids mutational evolution and host adaptation of SARS-CoV-2. Our findings demonstrate a conceptual breakthrough on the mutational evolution mechanisms of SARS-CoV-2 for human adaptation. SARS-CoV-2 may grab advantageous mutations from the widely existing microorganisms in the host, which is undoubtedly an "efficient" manner. Our study might open a new perspective to understand the evolution of virus mutation, which has enormous implications for comprehending the trajectory of the COVID-19 pandemic.

Theoretical analysis of the problem of developing personal resilience

Military operations on the territory of Ukraine have a devastating impact on the entire population of the state. Daily shelling, participation in combat, loss of loved ones, and the experience of prolonged stressful situations affect all areas of the population's life and, in particular, their psychological and mental health. An important task of modern psychological science is to explore ways to develop constructive ways to overcome stressful situations and develop personal resilience and counteract difficult life circumstances.In recent years, the study of the problem of resilience as the ability to resist life's difficulties has been actively developing. The study of this problem helps to solve many problems of practical psychology, since the development of resilience and the ability to resist stressful situations is a necessary component of the personality in wartime.The article presents a theoretical generalization of scientific approaches to the study of the concept of resilience. The main directions in the study of resilience of foreign and domestic authors are revealed. Various factors and determinants that influence the development of resilience as a process of resistance to stress are analyzed. The historical dynamics of understanding and studying the concept of resilience and the study of the development of personality resilience are presented.Based on the results of the theoretical analysis, we can distinguish the following scientific generalizations of the concept of resilience: it has a dynamic nature and biological basis, is an important prerequisite for successful adaptation and development of the individual, can be considered in social, biological or psychological aspects, its development depends not on the living conditions of a person, but on his/her perception of life difficulties, during the emergence of difficult living conditions, as well as in the process of experiencing life difficulties, a person is capable of post-traumatic growth and resilience.There are four stages in the study of the concept of resilience:1. Identification of signs based on longitudinal studies of children's defensive functions.2. Identification of the process. During this stage, the focus of the study changes from defensive factors to consideration of human resilience processes.3. The third stage is based on the first and second, it actively considers resilience as a mechanism that leads to positive human adaptation in adverse conditions.4. The fourth stage was caused by the development of technologies that allowed to study resilience more qualitatively with the help of psychodiagnostic tools.It has been established that resilience is an individual ability to counteract and find constructive methods of overcoming stressful situations, an important prerequisite for mental adaptation and personality development. Resilience depends on the influence of external (social) factors and individual psychological factors.